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Secret agent Jacques Kristoff (Jean-Claude Van Damme) is assigned to escort Galina Konstantin (Laura Elena Harring), a thief in possession of a deadly virus, on a train journey that unluckily falls on his birthday. Kristoff tells his disappointed wife, son and daughter that he’s taking a business trip. They decide to sneak aboard the train as a surprise, only to suspect he’s having an affair with the mysterious Galina. To make matters worse, terrorists hijack the train and go after the virus.