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With stolen top-secret technology, terrorists have created a next-generation Universal Soldier – an elite fighter genetically altered into a killing machine. With this Universal Soldier (Andrei Arlovski) leading the way, they seize the crippled Chernobyl nuclear reactor, threatening to unleash a lethal radioactive cloud. The only one who can stop them is Luc Deveraux (Jean-Claude Van Damme), a decommissioned Universal Soldier. Reactivated and retrained, Deveraux must make a full-out assault on the heavily armed fortress.