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ISA Agent Jon (Jay Chou) is on a dangerous mission to escort a criminal scientist to another country. En route, a member of his team, Sean (Andy On), turns out to be a traitor and shoots Jon in the head while kidnapping the scientist. When he wakes up in hospital, a doctor tells him that within weeks the bullet in his brain will cause complete paralysis. Jon returns to Beijing to see his mother, who confesses that he has a brother, Yeung (Nicholas Tse), in Malaysia. While on a flight to find Yeung, he forms a bond with a doctor (Issam M. Husseini) who promises to look into possible treatments for his condition. However, when they arrive, Yeung tries to kidnap the doctor and when Jon intervenes, he’s also taken hostage. The two soon realise they’re brothers, and decide to work together in order to find the people who tried to kill Jon.