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Dr. Eli Watt (Lionel Barrymore), a widower, moves to a small New England town, considering himself to be a failure. He raises his son, Jimmy (Buster Phelps), as well as Letty, a baby whose mother died in childbirth and whose father abandoned the child after blaming Watt for his wife’s death. Watt dreams of returning to do research studies, but he always finds something getting in the way – an epidemic, his children’s needs, or the needs of his patients. Only with the passing years does he come to find that his future isn’t over and he isn’t the failure he thought he was.