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Philip (Steve Martin) manages a suicide-prevention hotline called ‘Lifesavers’, assisted by Mrs. Munchnik (Madeline Kahn) and Catherine (Rita Wilson). On Christmas Eve, Philip learns that their landlord, Stanley (Garry Shandling), is evicting them from their office. Amid all this unrest, Catherine proclaims her love for Philip. Things get even more complicated when an array of individuals including a transvestite, Chris (Liev Schreiber), and a pregnant woman, Gracie (Juliette Lewis), enter the already manic office.