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Nikki Collins (Deanna Durbin) witnesses a brutal murder while travelling on a train to New York City. Although, she desperately tries to inform others of what she saw, no one believes her. In her scramble to convince someone of the crime, she finds an ally in a mystery writer, Wayne Morgan (David Bruce). Trapped on the train, the more Nikki tries to raise the alarm, the more attention she draws to herself – and the killer is starting to notice.