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Akbar is a powerful figure of Mangalore underworld who shares his business lead with Mani Menon and Uncle Sam , two other prominent gangsters ruling the city. The city remains calm under them, until Anto, grandson of uncle Sam, and his foreign associate Tom, come up with a new idea of importing used vaccines from abroad at very low rates and selling them at higher price. Akbar, who is against the business of drugs opposes it. This causes Anto to turn against Akbar and he makes plans to kill him. In the attempt, Akbar gets injured badly and loses his wife, Sana. What follows is the comeback of Akbar to avenge his loss.