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Dr. Bill Cortner (Jason Evers) is a successful scientist with a beautiful fiancée named Jan Compton (Virginia Leith). After a horrible car accident decapitates his fiancée, Dr. Cortner collects her severed head and rushes it to his laboratory, where he revives it and manages to keep it alive in a liquid-filled tray.
The Doctor now decides to commit murder to obtain an attractive new body to attach to his fiancée’s head. As he hunts for a suitable specimen, Jan begins to hatch some murderous plans of her own.
Filled with hatred for Cortner because he won’t let her die, she communicates telepathically with a hideous mutant in the laboratory cell, telling it to kill the scientist.