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Shock tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a comatosed state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her.
As Stewart comes out of shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at his nurses, Elaine Jordan (Lynn Bari), urging, gives Stewart an overdose of insulin under the pretense of administering insulin shock therapy. He can’t bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Franklin Harvey (Charles Trowbridge), saves Stewart’s life and Dr. Cross is arrested.